Osteodystrophy Gall

Osteodysplasia of the bile ducts is a rare systemic disease, which is characterized by the appearance of foci of atrophy and osteoporosis in the neck of the gallbladder.

In 1959, the German surgeon Graeb argued that patients with cholelithiasis often have spontaneous bile hyperhyperosis, which causes a disturbance in the homeostasis of calcium salts. Under the influence of these manifestations, bile salts enter the periprostatic bone, causing abnormal lime deposition. However, after some time, the pathological tissue is replaced by bone tissue, thereby restoring homeostasis. Such changes are associated with a chronic inflammatory process, and this, in turn, provokes activation of the gene that controls the regeneration of osteoblasts.

According to Graeb's theory, osteodysplasia of the biliary tract can also be caused by hereditary factors, which is confirmed by cases of the disease in children of several generations. Perhaps this side effect is caused by congenital deformations of the gallbladder or changes in its structure. The main risk factors are gallstones, general necrosis of the bile duct valves due to prolonged pancreatitis, chronic colitis, biliary dyskinesia.

Pathology occurs in two ways. It can only be visible using instrumental methods, and gradually atrophies the mucous membrane of the bile ducts and bone tissue. In this case, the course of the disease is asymptomatic; only changes on the radiograph can be observed. The bone tissue first thickens, then gradually shrinks, dotted and banded calcifications appear in the mucus