Double Block

Double block is a neuromuscular conduction disorder that occurs when two or more drugs are used simultaneously, each of which can cause conduction disturbances. One of the most common examples of a double block is the use of a depolarizing curare-like agent, such as succinylcholine, and an antidepolarizing neuromuscular blocker, such as tubocurarine. This can lead to the development of a double block, which can lead to serious complications such as paralysis of the respiratory muscles and cardiac arrest.

To prevent double block, it is necessary to choose and combine medications correctly. In addition, it is necessary to carefully monitor the patient's condition during anesthesia and monitor for possible side effects from the use of drugs.

Double block is one of the main and most common errors in the practice of using neuroleptanalgesia (NLA), as well as local anesthesia. It is believed that these drugs can cause neuromuscular conduction disorders of the anti-depolarizing block type.

The administration of drugs such as propofol and thiopentone can lead to partial and even temporary blockade of conduction. The technique of administering these drugs is based on this mechanism. Typically, atropine is administered first to reduce concentrations and prevent bronchospasm, followed by a drug for second-stage anesthesia or general anesthesia. Anti-depressants are then added to block the neurons in the brain. For local anesthesia, the procedure is also similar.

However, drugs containing such components may affect peripheral nerves, especially if the patient is taking the drugs listed above or is used under hypoxic conditions. For example, therapy to treat corneal hypersensitivity, unless absolutely necessary, can also impair the transmission of nerve impulses. In medicine, double blockade can be divided into two types: prolonged and non-prolonged blockade. With a prolonged double block, the pain lasts longer, while with a non-prolonged double block, the pain can last up to several hours. Both types of double block can be caused by local painful irritation from analgesic drugs or repeated administration of anesthetic drugs that should not be used simultaneously.

If the patient is treated with drugs that cause double block, the pain will remain for a long time. This condition can be very serious. This is why patients should avoid using these drugs during treatment with local anesthetics. Doctors should study this issue and discuss the risks and benefits of local anesthesia in each case.

Patients may have body conditions that may cause double block.