Forbes-Albright Syndrome

Forbes-Albright Syndrome: Description, causes and treatment

Forbes-Albright Syndrome (FOS) is a rare genetic disease that is characterized by impaired calcium metabolism in the body and can lead to various complications such as osteoporosis, osteomalacia, bone deformation, hypercalciuria and others.

The syndrome was named after two scientists: Arthur P. Forbes and Fuller Albright, who first described it in 1942. The syndrome is also known as Argonza-Forbes-Albright Syndrome because in 1978, Spanish physician Arturo Argonza also described similar symptoms in his patients.

The cause of FOS is a malfunction of the parathyroid glands, which are responsible for the production of the hormone parathyroid hormone (PTH), which regulates the level of calcium in the blood. With FOS, hyperplasia of the parathyroid glands occurs, excessive release of PTH and, as a consequence, hypercalcemia (increased levels of calcium in the blood).

Symptoms of FOS may include bone pain, muscle weakness, headaches, nausea, vomiting, frequent urination, and others. Some patients may experience depression, anxiety, insomnia and other psychological disorders.

To diagnose FOS, various methods are used, such as a blood test for calcium and PTH levels, X-ray examination of bones, ultrasound examination of the thyroid gland and others.

Treatment of FOS may include surgical removal of the parathyroid glands, carried out if there are certain indications. Medications to lower blood calcium levels and reduce the release of PTH may also be used.

FOS is a rare disease, but its consequences can be serious. If you suspect FOS, you must consult an endocrinologist for diagnosis and prescribing the necessary treatment.

Forbes Albright Syndrome

> Forbes-Albright-Kimmelstiel or **FORBES** (English Forbes-Albright-Kimmerling syndrome) is a rare hereditary disease from the group of X-linked recessive disorders, the genetic defect of which is a heterozygous mutation in the PAX6-BP1 gene. Characterized by gonadal damage, skeletal disorders, and skin hyperpigmentation. First diagnosed in 2002. Named after the names of its first descriptors David Forbes, Fay Albright and Gregory Kimmelstiel. Link: Wikipedia https://ru.wikipedia.org/wiki/FORBES