Heparinization Regional

Regional heparinization

Regional heparinization (HR) is a method of performing heparinization in which heparin is introduced only into the perfusion device and is then inactivated when leaving the device. This method avoids the entry of heparin into the systemic circulation and reduces the risk of thrombotic complications.

G.B. is one of the most common methods of heparinization under conditions of artificial circulation (CPB) or hemodialysis. Under these conditions, G.r. can be used to prevent thrombosis in patients at high risk of developing thromboembolic complications, such as patients with artificial heart valves, after cardiac and vascular surgery, as well as patients with chronic renal failure.

When performing HR, heparin is first injected into the perfusion fluid, which circulates through the perfusion pump. Heparin is then inactivated by adding a special anticoagulant such as sodium citrate or heparinase. After completion of the procedure, heparin is no longer present in the patient's blood, which reduces the risk of thrombosis.

Advantages of G.R.:

– Reducing the risk of thrombotic complications;
– Less risk of developing heparin intoxication;
– Reducing the time of the heparinization procedure;
– Possibility of use in patients with an increased risk of thromboembolism.

However, G.r. It also has some disadvantages. For example, due to the lack of systemic exposure to heparin, a higher dose of heparin may be required to achieve the desired blood concentration. In addition, G.b. cannot always be used in all patients, as some perfusion devices may have restrictions on the volume of heparin.

In general, G.b. remains one of the most effective methods of heparinization and can be used in a variety of settings, including IR and hemodialysis.

Without welcoming you today, I want to share with you an important method of treating cardiovascular diseases - regional heparinization. This method is relevant, because already at the beginning of the new millennium, among the 150 million inhabitants of the Earth, 1.2 billion people already lived with arrhythmias and disorders of the heart structures, which amounted to 85% of the population over 65 years of age [1].

The first cardiologist who drew attention to the role of thrombus formation in the development of myocardial repolarization disease, regardless of age, was Mossido de Loches. Gradually, this therapist began to use heparin preparations to eliminate the formation of blood clots. But its effectiveness was low. Under more careful study, its use turned out to be ineffective, because the blood, which contains particles of heparin, fibrins and many other substances and trace elements, could form even more clots than were absent before and turn the disease into an even more dangerous one. At the same time, the tactics of chipping were proposed; it was convenient in that