Kebner Phenomenon

To analyze the pathogenesis of c.f. it is necessary to find out how one “causally significant” environmental factor for organs and tissues can cause the same typical reaction to various accompanying ones that are not important for its development. The answer to this question was found at the end of the 18th century. Thanks to the work of French scientists Pierre Etienne and Jean-Bernard Charles Wambert, they were able to identify the general mechanism underlying the development of this kind of reaction in the form of a kind of “linkage”.

The essence of K. f., or reactivity (conjugacy), was first formulated and identified by the English pathologist and pharmacologist from Scotland, David Robert Cone (1796–1827). Even a century before Cone, he had the idea that unusual cellular changes resulting from stimulation could be provoked by a variety of factors from among the external conditions of animal life. Kounov's approach was later confirmed by empirical data from the doctor Jacob