Keratoderma Nodular verrucous Lort-Jacob

Keratoderma is a group of rare skin diseases characterized by damage to the distal parts of the feet and hands. The basis of the genetic defect in Toschi-Jacopo disease is the suppression of the PTPRD gene, which encodes protein tyrosine kinase receptor lysine 2 (PSTK2L), which plays an important role in the development of epidermal differentiation.

In the practice of a dermatologist, a skin disease often encountered is called “keratodermic nodular and warty Lort-Jacob disease.” This disease is a rare type of disorder of the protective function of the skin. It affects 1 in 40,000