Methemoglobinuria

Methemoglobinuria is a rare disease characterized by increased levels of methemoglobin in the blood and its appearance in the urine.

Methemoglobin is an altered form of hemoglobin that is unable to carry oxygen. Under normal conditions, a small amount of hemoglobin is constantly oxidized to methemoglobin, but is then reduced by the enzyme systems of red blood cells.

With methemoglobinuria, this process is disrupted, and the amount of methemoglobin increases sharply. Excess methemoglobin leads to tissue hypoxia, since oxygen delivery to tissues is reduced. Methemoglobin is excreted in the urine, giving it a characteristic brown color.

The main causes of methemoglobinuria are medications, poisoning (nitrates, aniline), as well as some hereditary diseases. Treatment consists of eliminating the cause and introducing restorative agents.

Methemoglobinemia is a rare congenital disease of hemoglobin metabolic processes, in which it turns into the form of methemoglobin due to a violation of the structure or synthesis of proteins that ensure its breakdown. In terms of morphological and biochemical properties, methemoglobin hemoglobin differs little from normal hemoglobin, since it is the product of a catalytic reaction between hemoglobin and an aryl dinitrogen reagent.

Deficiency of the cellular enzyme G-6-FDG. It provokes congenital malformations: neurological abnormalities, changes in the formation of internal organs and pathological changes in the eyes. The danger of this condition is that