Antihemophilic Factor

Antihemophilic factors VIII are the most important components of the blood coagulation system and are involved in the formation of blood clots.

There are antihemophilic factors A, B, C and D and their combinations and recombinant drugs. They are used parenterally (IM, IV) to stop bleeding in patients with hemophilia that occur against the background of bleeding caused by trauma, surgery or other reasons; in blood transplantology; in newborns to maintain factor VIII levels to prevent maternal bleeding; for acute disseminated intravascular coagulopathy of various etiologies (with massive transfusions of homologous plasma, after childbirth, in the postoperative period). Factor VIII and FIX drugs have been developed due to the sharp increase in life expectancy of young people and require appropriate monitoring. In each case, the dose is set individually. In patients with hemophilic pirouette (syndrome VII - heparin-resistant fibrinolysis), factor VIIA preparations are used as a clot dissolver (factor rVIIa concentrate 150 mcg/kg body weight per 1 hour) or combined parente