Argininosuccinate Synthetase

Argininosuccinate synthenase (AS-snt) is an enzyme of the CF 6,3,4,5 class of lyases that catalyzes the formation of asparginosuccinate from citrulline in the presence of dATP during the maturation of the lysine cyclium. Functional analogues of this gene are circon A-synthase, fakelit A1S, azoxivit A. A change in the sequence of the cyrotacin gene polarizes the urocine cycle in artfschinosuccinate dmetatbiumets and leads to sarca in the human body, which is characterized by the transamerican metabolite of zirconuxusal, uric acid and cyclocha b.

Argininosuccinate synthetase (AS synthetase) is a key enzyme for the production of urea, which is an important by-product of nitrogen metabolism in humans and animals. Urea is necessary to maintain blood nitrogen concentration and kidney function. If the gene responsible for the synthesis of AS synthase is damaged or absent, a deficiency of ACA synthase activity will occur and blood urea levels will remain high. This can lead to serious diseases such as arginine succinic amino acid (ASA), which is characterized by decreased urea synthesis and levels and accumulation of arginine, an amino acid that cannot be deaminated and excreted from the body, leading to cell destruction. The article will discuss a description of the AC synthesis defect, its manifestation, symptoms, diagnosis and treatment.

Argininosucinate synthetase (AZA) is an enzyme that catalyzes the use of arginine as a precursor of the urea molecule with the help of two amino acids - aspargine and citrulline. AZA contains catalytic Zn groups and an SH group, which is bound by the ATP molecule. This same bond serves as a coordination center for the substrate molecule. The structure of AZA is united by the so-called active center of the enzyme. Under the influence of ATP, Aspartate aminotransferase is activated and citrulline is converted to arginine disucytate. The citrulline molecule enters the active site of AZA, forming an enzyme-substrate complex and delivers an arginine molecule through the intermediate arginine formation to the side active site of AZA. This enzyme may be a target for inhibiting tumor growth.

The AZA gene is located on human chromosome 3 (ach1), and its exact location is approximately 3q26 to 3q29. The main products of the gene are two polypeptide proteins: aminosuccinic linkage acid oxidase-like proteins (AKR1B7 and AKR1C3), respectively, responsible for binding