Beka-Ibrahim Disease

Beck's disease is an acute, rarely chronic condition caused by the presence of antibodies to autoantigens of human tissue and characterized by multiple clinical signs of a neurological nature: extrapyramidal hyperkinesia (choreiform, athetoid movements) or hypokinesia. The variety of clinical manifestations is due to the insufficient specificity of a number of diagnostic criteria used in different countries to identify morbus.

Currently, hereditary or genetic (with various types of changes in the MBP gene) and hereditary infectious forms of the disease are distinguished. When they occur, IgG antibodies directed against MBP or desmin are detected in the serum. A predisposition to the formation of autoantibodies is inherited. The entry gates of infection for MBD are neutrophils, microbes that infect body tissues not during primary infection, as in enteroviral diseases or chronically affected children; with each generation there are more patients with autoimmune diseases (for example, Leigh syndrome). To detect auto