Brisseau-Marie Syndrome

**Brissot-Marie syndrome** is a neurological syndrome that is characterized by progressive weakness and pathological tremors of the eye muscles caused by damage to the cerebellum. This is a rare neurological condition that affects 1-2 people per 1 million population, but is known as traumatic brain injury, the most common type of which is subarachnoid hemorrhage.

Brissot-Mario syndrome was first described by the French physician E. Brissot (1852-1906) and the French neurologist P. Marie (1851-1926). They described a combination of progressive slow abnormal eye movements and impaired muscle tone in a patient with subdural hematoma hemorrhage. Although these syndromes are manifestations of TBI, they are more typical of cerebellar lesions, which may have a relatively low incidence of disease.

Brissot Marie syndrome is a rare complication of cerebrovascular disease, a manifestation of hemorrhagic stroke. The pathology is characterized by a combination of pathological muscle activity and loss of muscle strength of varying severity. The condition manifests itself as a slow, mild tremor of the eyelids (up to 3-5 movements per second), usually unilateral or bilateral, the lower motor neuron is poorly controlled. The eyelid lifts more noticeably on one side than on the other. When the eye moves, the height of the lower jaw in the shape of a Latin S decreases - a collar symptom. Other symptoms of the disease are rigidity and paresis of the muscles of the upper limbs. Damage to the glossopharyngeal nerve results in hoarseness. The function of the pelvic organs is reduced due to a decrease in motor activity of the pelvic floor muscles. Autonomic disorders are characterized by lability of blood pressure and pulse, hyperhidrosis, impaired sweating, and arrhythmic interruptions in the heart. The syndrome occurs with high amplitudes and slows down until it disappears as the hemiplegia decreases. However, the return of the original disorders is accompanied by a rapid resumption of symptoms - this is a clear sign of cerebellar damage in Marie Brissoit syndrome. Normally, such a relationship does not exist.

The presence of pathological tremor is due to a combination of pathology of the extrapyramidal and pyramidal systems. Clinical and electrophysiological studies have proven that the flickering protective reflex of the eye is caused by cortical and extrapyramidal influences (ectopic vestibule

Brisso Maria (Marie Charlotte) is one of the first female scientists, a neuropathologist of the 19th century. Marie began studying nervous diseases and was especially interested in multiple sclerosis, syphilis, epilepsy, Parkinson's disease, and progressive paralysis.

In 1874, her “Paris Clinical School” was the first to conduct a comprehensive examination of patients with progressive neuropsychiatric disorders, not only in psychiatry, but also in neurology, endocrinology, toxicology, bacteriology and other areas of medicine. She studied the effects of alcohol, hydrogen sulfide sources, and endocrine glands; released pathogenic metabolic products.

Maria Brissot observed severe neurological disorders and mental disorders in patients in serious condition. Her undoubted contribution to the doctrine of neurosyphilis lies in the first scientific studies that determined the diagnosis of this disease, that is, she was a pioneer. Thanks to

Brissot Marie syndrome (BMS): A syndrome associated with defects in neural connections in the brain. The syndrome is characterized by impairments in cognitive function, including decreased attention, memory, and learning ability. BMS is thought to be associated with genetic, epigenetic, and environmental factors on brain development during pregnancy. Research on this topic continues, but at the moment it is a rare disease that requires an integrated approach to diagnosis and treatment. In the context of neuroscience, the BMS represents an important target for studying neural plasticity, the organization of cortical structures, and the development of brain networks during the formation of new behavioral skills and cognitive functions.