Haley-Hailey Disease

Haley-Hailey Disease: symptoms, causes and treatment

Haley-Hailey disease, also known as hyperkeratosis disease, is a rare inherited skin disorder. This disease is characterized by the appearance of red, itchy patches on the skin that may be covered in white scales. The disease got its name in honor of two American dermatologists - Walter Haley and James Haley, who first described it in 1939.

The cause of Haley-Hailey disease is an inherited defect in the genes responsible for producing a protein necessary for the normal functioning of skin cells. This defect causes protein to accumulate in skin cells, resulting in red spots and scales.

Hailey-Hailey disease can manifest at any age, but usually begins in childhood or early adolescence. Symptoms may include red patches on the skin that may be painful or itchy, as well as scaly skin. The skin may also become thicker and rougher.

Diagnosis of Hailey-Hailey disease includes a general skin examination and medical history. Skin biopsies and genetic tests may be performed to confirm the diagnosis.

Treatment for Hailey-Hailey disease is aimed at reducing symptoms and preventing complications. Treatment may include corticosteroid and antibiotic ointments to reduce inflammation and infection, as well as ointments to soften and moisturize the skin. In some cases, systemic treatment, including the use of immunosuppressants, may be required.

Haley-Hailey disease is a rare but serious inherited skin disorder. If you notice symptoms of this disease, consult a dermatologist for diagnosis and treatment. Regular skin care can help reduce symptoms and prevent flare-ups.

Hailey-highy is a rare skin condition characterized by chronic itching and recurring rashes of small blisters. In the language of dermatology, Haley's disease - Haley's disease is called “keratoma rosea”.

Around the age of 60, every twentieth person begins the process of gene mutation, leading to a change in the structure of cells throughout the body. In this case, skin cells are affected. Although the pathogenesis of the disease is not well understood, scientists suggest that genetic disorders underlie the disease.

One of the genetic defects is a mutation, which consists of replacing one amino acid in the IKBKG (interleukin-1 receptor) gene with another. Such a change is fraught with disruption of the immune system. The body responds to the appearance of new cells with increased production of various substances: from chemical carcinogens to prostaglandins. There is no exact answer to the question of why different types of cancer develop with this tendency: from lung to kidney.

Pathology most often manifests itself only in people of Asian origin (including the Chinese,