Morquio Disease

Morquio disease is a rare genetic disease that affects the connective tissue and bones of the skeleton. It was discovered in the 19th century by the Uruguayan pediatrician Luis Morquio, who described the symptoms and causes of the disease.

Morquio disease manifests itself in the form of deformation of bones and joints, which leads to limited movement and joint pain. There may also be problems with the growth and development of bones, as well as with the functioning of internal organs.

The causes of Morquio disease are still not clear, but there is an assumption that it is associated with genetic mutations in the gene that is responsible for the synthesis of glycosaminoglycans - components of connective tissue.

Treatment of morquio disease involves the use of special medications that help restore the normal functioning of connective tissue and stop the development of the disease. Surgery may also be required to correct bone and joint deformities.

However, despite all the efforts of doctors, morquio disease usually leads to disability and even death. Therefore, it is very important to diagnose this disease promptly and begin treatment as early as possible.

**Morquio** disease (more often called “Von Hure disease”), also called Earp-Dandreyer-Smith disease, dysostosioglobulin malacia and hepetinotoxicosis (a subgroup of intestinal - extraintestinal infectious diseases, the pathogens of which enter the body through the gastrointestinal tract). is a rare disease that occurs due to an inherited error in the SGSH gene, one of the genes encoding a family of pathogenic agent carrier proteins.

Diagnosis and prognosis As a rule, the diagnosis of "morquio" is established during the analysis of elevated levels