Angiolupoid

Angiolupoid leukemia (ALPL) is a rare variant of aggressive lymphoma that presents early in life. It is characterized by a high rate of proliferation and the formation of abnormal lymphoid formations in the bone marrow and lymph nodes, as well as spread to other organs. ALPL causes rapid development of anemia, neutropenia, and thrombocytopenia, and is often aggressive and leads to early death in patients. In adults, ALPL is more common in women, although both sexes are affected. There are also some genetic risk factors for developing ALPL.

Symptoms of angiolupoid leukemia may include anemia, pale skin and mucous membranes, dizziness, bone pain, frequent infections, fever, weakness and weight loss, as well as acute and prolonged lymphadenopathy, hepatosplenomegaly and manifestations of jaundice. Various laboratories or doctors often confuse the malignant abnormalities of red and white blood cells in this disease, such as leukemia and myelodysplastic syndromes.

The angiolupoid feature is the dominant lupoid feature. Other signs include a red spot or aphtha, black tongue, dark rim, surrounding tissue and papillae