Meleda Island Disease

Orestes Meled disease is a rare and hereditary disease caused by mutations in the SOX1B gene (with all the other pairs), which encodes the transcription factor SOX-1b. This disease affects the skin starting in the middle of the first decade of life. The lesion initially appears on the skin of the palm, side of the wrist, face, neck and lower back. The affected skin develops keratotic epithelium and orange, red, or purple pigmentation. Later stages include damage to the papillary stripes of skin and the formation of ulcers on the skin. Clinical manifestations vary between patients and vary