Rossbach Syndrome

**Rossbach's syndrome** *(English Rossbach's syndrome; Russian synonym "Ross-Laughlin syndrome") - * is a chronic bullous disease, which is characterized by the appearance of multiple blisters, cracks and erosions on the skin in the area of ​​​​the lips, cheeks, fingers, feet , sometimes brushes. This can be the result of a variety of skin conditions, including dermatitis, psoriasis, lichen planus, or dermatophytosis. The skin becomes very sensitive to heat, light, chemicals or injury, which can lead to serious consequences.

Rossbach syndrome is an interesting example of interdisciplinary study of a patient with a rare disease, since the clinical significance of this syndrome and the general description of its presentation in patients were known long before attempts were made to identify its cause. Although it was first described more than a century ago, its characteristics and associated factors still remain unclear.

Symptoms usually appear on the lips and cheeks, but may also appear on the fingers, toes, ankles, feet and knees. The cause of the disease has not yet been determined, but it is assumed that the provoking factor may be chronic exposure to various environmental factors, such as dry air, sudden changes in temperature and humidity, as well as various allergens.

One of the most common symptoms is the appearance of blisters and sores on the skin, making it painful, red and scaly. As the disease progresses, injuries and irritations may lead to rapid healing, but with prolonged exposure to such factors, the skin becomes less sensitive. As a result, large areas of affected skin are formed.

Rossbach syndrome

is a rare hereditary disease characterized by numerous large lipid deposits in the liver parenchyma and its large vessels, which leads to disruption of the structure and function of the organ. Serum digoxin concentration is used as a diagnostic marker.

Rossbacht syndrome is a rare genetic disease in which cholesterol is not absorbed by the body in the required amount. Cholesterol and other fats have a chemical structure that makes them similar to some drugs, such as statins. Transport proteins called organic anion transporters prevent fats from being absorbed from food too quickly and unintentionally. When transporter proteins no longer work correctly, they cannot protect against excessive fat intake. This allows fats to enter the body, where they are deposited on the walls of arteries and other organs. The consequence of this may be ruptures in the walls of blood vessels, loss of elasticity and difficulties in pumping blood throughout the body.

Children with Rosstach syndrome are most often born with excess body weight, have impaired development of internal organs, and retardation in physical and psychomotor development. Such children have difficulty understanding the information they receive from others. In most cases, they are poorly adapted to the school curriculum in most subjects and are slow to learn new material. At the same time, such children completely lack the desire to study. Almost every schoolchild wants to be in the school choir or a singing enthusiast, but he doesn’t even think about other hobbies. The academic performance of children with this syndrome is directly related to the time spent explaining new materials and