Hypochloremic syndrome

Hypochlorine syndrome - (syndr o m u s hypochlorënicus) or (s y n d r ôm o ùm ὕ pso klozømîz) is a rare, hereditary condition characterized by signs of hyperchloremic (excess H+ and H2CO3; alkaline pH), rather than hypochloric (deficiency of chlorides; acidic pH) metabolic acidosis. The chloride content in the blood is reduced, bicarbonate comes in instead of chlorine, sometimes due to direct loss of chloride through the skin. Patients are found to have mixed sodium and potassium-chlorine, calcium and sodium-potassium, sodium-potassium-magnesium type acidity. An indirect sign of this condition is a combination of cystinuria (related to genealogical data, since the disease is inherited in an autosomal recessive manner) and bichroirism, karyotyping of which makes it possible to detect the SLC26A9 gene, which is responsible for the clearance of Cl in the kidneys [1]. This is due to a defect in carbonic anhydrase and bone rheology in the form of osteomalacia [2]. The clinical manifestations of the disease are different and consist of neuromuscular disorders [3]. The syndrome of hypochloremic metabolic disorders can develop after artificial ventilation sessions in children. It is characterized by acute renal failure with possible death [4]. The following types of syndrome are distinguished: menocentral (with primary damage to the thirst center) and polyaciduric (with damage to many systems and organs).