Vincent-Alajuana Syndrome

Vincent-Alajouanine Syndrome (VAS) is a rare and serious neurological disease that is characterized by neurological disturbances such as drowsiness, confusion, seizures, and in some cases, even coma for several hours or days. . The syndrome was first described in 2007 by French neurosurgeon J.C.D.Vincent and neurologist T. Alajouanine.

Symptoms of Vincent-Alajaoine syndrome appear in various forms. In most cases, patients complain of drowsiness and fatigue, loss of attention, slow reactions, difficulty concentrating, memory loss, dizziness, ataxia, confusion and sometimes even coma. Some patients may have seizures and other symptoms such as insomnia, loss of taste or smell, or speech impediments

Vincent–Alajouanie syndrome is a rare genetic disease that affects the nervous system and leads to various disorders. It was described by the French neurosurgeon Vincent Alajouanin in the 19th century, and then by the pathologist François Alford Hoth at the end of the 19th century and his student François Jacob Pasteur at the beginning of the 20th century. Since then, the disease has been studied by many researchers, but still remains poorly understood. The syndrome causes many problems for patients, especially during childhood, as it can lead to various complications such as mental retardation, movement disorders, epilepsy and even death.

Disturbed metabolism in nerve cells resulting from the disease. In the process of exchange between brain cells, amino acids accumulate, which have a structural feature - toxicity towards axonal membranes, which causes a change in neurotransmitter activity and disrupts interneuron connections. This can lead to disruption of certain areas of the cerebral cortex, which is manifested by symptoms such as headaches, weakness in the arms or legs, mood changes, drowsiness, memory impairment and learning difficulties.

The main cause of the syndrome, identified through scientific research, is a mutation