Huntington's chorea

A genetic disease (birth defect) that occurs in a person under the influence of a mutation in a gene with the so-called. HTT; rarely occurs in humans, more often in animals. There are only a few described cases of heterozygous carriage in humans, the so-called X-linked behavioral variability. Dominant inheritance with incomplete penetrance. Protein inclusions in Huntingon's disease are detected by microscopic examination only several years after the onset of the disease and in small quantities in the affected muscles and skin.

Generic chorea (hereditary degenerative chorea disorder; HC, GH) is a heterogeneous group of neuropsychiatric disorders of varying severity, inherited in an autosomal dominant manner, polygenic familial mutations, and characterized by slow, tremulous, irregular and stereotypical movements of varying volume and amplitude, representing chaotic, irregular chains, a set of vibrations and repetitions, sometimes clinically reminiscent of certain dance steps and choreic dances. It is popularly abbreviated as chorea or choreia. Episodic choreo-like manifestations periodically occur in patients with diffuse parkinsonism, Alzheimer's disease and psychopathic disorders. Chorinescence develops in idiots. Cerebellar agenesis in most cases is combined with epilepsy and severe mental retardation. Syphilitic parkinsonism has multiple lesions in the brain. A Parkinson-like condition may be the result of a tumor of the medulla oblongata, isolated injury to the frontal lobe, damage to the “motor” zones of the cortex, thalamus or basal ganglia, occurring during transient ischemic attack, myasthenic crisis and paraneoplastic syndrome, anemia, hypothyroidism, arterial hypertension, hypertension, heart disorders rhythm, atherosclerosis of cerebral vessels or thrombosis of cerebral arteries. All cases of movement disorders of extrapyramidal localization due to intoxication should be classified as chorea.

The sectional material is dominated by cases with neurochemical disorders of cerebral chorea. Observations indicate the possibility of recording generative choreas of various etiologies (idiopathic, caused by hematogenous or other transorbital routes, hereditary) detected in primary or secondary resistant cases. In models of micronuclei and submicroscopic proliferation defects or due to complete loss of chromatin or changes in its morphology. Clinically Chore