Asthenia Total

Total asthenia (asthenia totalis) is a rare hereditary disease characterized by severe muscle weakness, hypotension and impaired formation of connective tissue.

The disease manifests itself from birth or in early childhood. There is general muscle hypotonia, decreased muscle strength, and joint dislocations. The child begins to hold his head up, sit, stand and walk late. Characteristic deformities of the chest, scoliosis, arachnodactyly.

The cause of total asthenia is mutations in the genes COL3A1, COL5A1, COL5A2, collagen types 1 and 3, which are responsible for the formation of connective tissue.

Synonyms: general congenital asthenia, asthenic disease, Stiller's syndrome.

Treatment of total asthenia is symptomatic - physiotherapy, exercise therapy, orthopedic correction. The prognosis is generally unfavorable due to its progressive course.

Total asthenia is a rare and complex disease that is characterized by general fatigue, weakness and low level of activity. This condition can occur in people of any age, but is most often seen in children and adolescents.

Causes of asthenia can vary, including genetic factors, environmental exposures, infections, injuries, and certain medical problems such as thyroid or adrenal gland disorders.

Clinical symptoms of asthenia may include loss of appetite, headache, fatigue, dizziness, decreased energy levels, sleep disturbances, decreased attention and concentration, mood changes, and some patients may experience fever and weight loss.

Diagnosis of total asthenia may require a comprehensive examination by a doctor. First of all, it is necessary to determine the cause of the disease - this may require additional blood and urine tests, as well as consultations with other specialists.

Treatment of total asthenia is complex and may include drug therapy, lifestyle changes,