Hemoglobin C

Hemoglobin C (HbC) is an abnormal hemoglobin that differs from normal hemoglobin A. It is formed by the replacement of glutamic acid with lysine in the beta chains of hemoglobin at position 6. Hemoglobin C is one of the most common hemoglobin abnormalities and occurs in many people around the world.

Hemoglobin C can be found in the blood of a person who has a genetic mutation in the gene encoding the beta globin chains of hemoglobin. This mutation can lead to the development of a mild form of hemolytic anemia, which is characterized by increased destruction of red blood cells in the blood.

However, in most cases, hemoglobin C does not cause serious health problems. However, people with a homozygous hemoglobin C condition (when both copies of the gene encoding beta globins contain a mutation) may develop a mild form of hemolytic anemia. This is because hemoglobin C binds oxygen less efficiently than hemoglobin A, resulting in decreased oxygen levels in the blood and increased destruction of red blood cells.

Various methods are used to diagnose hemoglobin C, including blood tests and genetic testing. Treatment may include red blood cell transfusions or medications that help increase oxygen levels in the blood. In general, hemoglobin C is a common hemoglobin abnormality that can lead to a mild form of hemolytic anemia in some people.

Hemoglobin C is an abnormal form of hemoglobin that is different from the normal form of hemoglobin called A. Hemoglobins are red blood cells that carry oxygen from the lungs to cells throughout the body. Hemoglobinopathies are certain disorders of the hemoglobin chains, which often have a genetic basis and can lead to various diseases, such as hemolytic anemia and perinatal complications. The formation of abnormal hemoglobins can be caused by mutation of one or more nucleotide bases in the hemoglobin gene ABORHPCSS. Abnormal hemoglobins can be classified as stable or unstable, depending on how well they are separated from normal hemoglobin. Sometimes the disease may not appear if a person has only one copy of the abnormal gene. However, if he carries two copies of this gene (homozygous carriage), then chronic disease of the red blood cell system progresses. With homozygosity, taking into account other polymorphisms, frequent repetitions in the pedigree confirm a high risk of developing B(12)-deficiency anemia in children (33 in boys and 48 in girls)