Hallermann-Streiff-Francois Syndrome

Hallermann-Streiff-Francois syndrome

Hallermann-Streiff-François syndrome (also known as mandibulo-oculofacial dysmorphia) is a rare hereditary disorder characterized by developmental abnormalities of the facial skeleton, eyes and jaws.

The main symptoms include hypoplasia of the malar bones and maxilla, wide-set eyes (hypertelorism), ptosis (drooping of the upper eyelid), coloboma of the iris and cornea, and dental abnormalities. Intelligence, as a rule, does not suffer.

The disease is hereditary and is transmitted in an autosomal dominant manner. The reason is mutations in the TWIST1 gene.

The syndrome was first described in 1936 by the German ophthalmologist W. Hallerman, in 1950 by the Swiss ophthalmologist E. Streiff and in 1966 by the Belgian ophthalmologist J. Francois.

Treatment is symptomatic and includes surgical correction of defects of the facial skeleton and eyes. The prognosis is generally favorable.

Hallermann-Streiff-François syndrome is a rare genetic disorder characterized by deformities of the skull, face, jaws and eyes, as well as some neurological and endocrine abnormalities. This condition usually appears in infants or children under 5 years of age, but can sometimes be found in adults.

The syndrome was first described in 2001 by German ophthalmologist Werner Hallermann, Swiss ophthalmologist Eberhard Streiff and Belgian ophthalmologist Jacques

In modern medicine, many new terms arise, but sometimes they are not clear to ordinary people. However, if a person gets sick, then he is ready to pay any price for health.

Hallerman Streiff Francois is a congenital underdevelopment and asymmetry of the jaw. Asymmetry appears due to low embryonic anlage and development of the parathyroid glands of the jaw and sinuses, as well as with disturbances in the development of the temporomandibular joint.

When diagnosed with Hallermann Streiff syndrome, a person sees all the flaws in his appearance, even the most harmonious proportions, which is why he has a bad mood and low self-esteem. If you do not pay attention in time, the symptoms only intensify with age.