L-Thyroxine 50 Berlin Hemi

Country of origin - Germany, Berlin-Chemie AG/Menarini Group Germany
Pharm-Group - Drugs that stimulate thyroid function

Manufacturers - Berlin-Chemie AG (Germany), Berlin-Chemie AG/Menarini Group (Germany)
International name - Levothyroxine sodium
Synonyms - Bagotirox, L-thyroxine, L-thyroxine 25 Berlin-Chemie, L-thyroxine-100 Berlin Hemi, L-Thyroxine-Acri, L-thyroxine-Farmak, Thyro-4, Eutirox, Eferox
Dosage forms - tablets 50 µg
Composition - Active ingredient - Levothyroxine sodium.

Indications for use - Hypothyroid conditions of various etiologies, suppressive thyroid therapy of simple (non-toxic) goiter, Hashimoto's autoimmune thyroiditis, multinodular goiter, thyrostatic treatment of hyperthyroidism (complex therapy) after achieving a euthyroid state, prevention of goiter relapse after resection, conducting a suppressive scintigraphic test of the thyroid gland, thyrotropin-dependent well-differentiated papillary or follicular carcinomas of the thyroid gland.

Contraindications - Hypersensitivity, untreated thyrotoxicosis, acute myocardial infarction, severe hypertension, angina pectoris, myocarditis, heart failure, tachysystolic rhythm disturbances, old age (over 65 years), uncorrected dysfunction of the adrenal cortex.

Side effects - Tachycardia, rhythm disturbances, chest pain, tremor, insomnia, anxiety, hyperhidrosis, alopecia, weight loss, diarrhea, adrenal dysfunction (with pituitary or hypothalamic hypothyroidism), renal dysfunction in children.

Interaction - Reduces the effect of insulin and oral antidiabetic drugs, cardiac glycosides, enhances - indirect anticoagulants, tricyclic antidepressants. Phenobarbital and phenytoin accelerate metabolic Cl without increasing the proportion of free T3 and T4 in the blood. Cholestyramine, colestipol, aluminum hydroxide reduce plasma concentrations by inhibiting absorption in the intestine. Protein binding is altered by anabolic steroids, asparaginase, clofibrate, furosemide, salicylates, tamoxifen. Estrogens increase the concentration of the thyroglobulin-bound fraction (efficacy decreases). Synthesis, secretion, distribution and metabolism are influenced by amiodarone, aminoglutethimide, para-aminosalicylic acid, ethionamide, antithyroid drugs, beta-blockers, carbamazepine, chloral hydrate, diazepam, levodopa, dopamine, metoclopramide, lovastatin, somatostatin and others.

Overdose - Symptoms: thyrotoxic crisis, sometimes delayed for several days after administration. Treatment: prescription of beta-blockers, intravenous corticosteroids, plasmapheresis.

Special instructions - It is recommended to periodically determine the content of thyroid-stimulating hormone in the blood, an elevated level of which indicates an insufficient dose. In case of long-standing multinodular goiter, a stimulation test with thyrotropin-releasing hormone should be performed before starting treatment. For elderly patients, the initial dose should not exceed 50 mcg. Prescribe with caution for severe, long-term hypofunction of the thyroid gland. When used in the second and third trimesters of pregnancy, the dose is usually increased by 25%. Before starting treatment, the possibility of pituitary or hypothalamic hypothyroidism should be excluded.

Literature - Encyclopedia of Medicines 2003