Alporta Syndrome

Alport syndrome is a hereditary kidney disorder that manifests itself in the form of glomerulonophyte, progressive deafness and other symptoms. It was first described in 1916 by James Alporta, a South American physician, who noted the relationship between the syndrome and seven carriers of the pathology.

A. Alport's syndrome is a fairly rare congenital disease caused by a violation of the structure of the basement membrane (straea and epididymis), which results in a number of hereditary pathological changes in the renal system in children and adults. In addition, there are indications of damage to the vascular bed, nervous system, organs of hearing, vision and speech.

The disease is inherited as a recessive trait linked to the X chromosome. As a rule, both eyes are affected, and deafness develops in approximately 75% of patients. Important risk factors include genitourinary surgery in childhood, as well as sports or other harmful exposures. In most patients, the disease is asymptomatic and is discovered incidentally in early childhood.