Glanzmann-Riniker Syndrome

Glanzmann-Rinikerovsky (Glanzmann, Rinker) syndrome is a rare disease that is characterized by changes in the properties of blood and an increase in its viscosity. Synonym: high plasma viscosity syndrome. The disease is being reported all over the world. It is believed that the incidence of Glanzmann-Riniker syndrome among the population of North America is several times higher than in Europe. This syndrome occurs in both sexes, as well as in infants. In any case, this is most often a hereditary problem. Genetic mutations entail changes in the blood plasma and its components, cells and tissues. Other causes of this syndrome have not yet been established. In patients with the disease, blood clotting time increases, the morphology of red blood cells changes, and edema appears. If help is not provided in time, this can lead to disruption of the cardiovascular system and cause death for the patient.

The occurrence of the disease in most cases is associated with mutations of genes on the X chromosome, but rare B-trisomy of chromosome 4 is also present. The HLA-GA gene is the main marker