Agenesis (Agenesis)

Agenesis is the congenital absence of an organ, usually associated with a defect or underdevelopment of the embryo.

Agenesis occurs when the formation of organ primordia is disrupted during embryonic development. As a result, one or another organ does not develop completely or is completely absent.

The most common forms of agenesis:

1. Renal agenesis is the absence of one or both kidneys.

2. Dental agenesis is the absence of one or more teeth.

3. Iris agenesis is the absence of the iris of the eye.

4. Agenesis of the corpus callosum is the absence of the corpus callosum of the brain.

5. Vaginal agenesis is the absence of a vagina.

The causes of agenesis may be associated with genetic mutations, chromosomal abnormalities, and the effects of harmful factors on the developing embryo. Agenesis is often combined with other developmental defects.

Treatment of agenesis depends on the specific organ affected and the degree of its underdevelopment. These can be surgical methods, prosthetics, hormonal therapy. The prognosis also varies depending on the form of agenesis.

Agenesis (Agenesis) is the congenital absence of an organ, usually associated with a defect or underdevelopment of the embryo.

This is a rare condition in which a person is missing one or more organs that are usually formed during embryonic development. Agenesis is caused by genetic disorders or damage to the embryo in the early stages of pregnancy.

Agenesis most often occurs in the kidneys, teeth, reproductive organs and pancreas. The absence of vital organs such as the heart, lungs or liver is usually incompatible with life.

Diagnosis of agenesis is based on the results of ultrasound, x-ray, CT, MRI and other imaging methods that can detect missing organs. Treatment depends on the specific organ and the degree of its underdevelopment. In some cases, transplantation or prosthetics is possible. The prognosis also varies depending on the extent of the lesion.

Agenesis or agenesis is a congenital anomaly where an organ or part of the human body is missing. Usually, the absence of an organ is accompanied by damage to the cardiovascular system, central nervous system, hematological disorders, skeletal and digestive pathologies. Children do not conceive or do not fully develop any organ, such as the liver, pancreas, gallbladder, larynx, heart, etc. The absence of one organ does not put much strain on other organs, so children usually survive. In this case, the operation is performed immediately after birth. The long-term existence of the defect negatively affects the patient’s future life and eventually leads to disability. The most severe forms of the anomaly are polyagenesis, Wiedemann-Beckwith, Shwachman, Keharta, Walkovich-Craig, and Di-Hippocrates syndromes. Some experts believe that certain parts of the body may be underdeveloped while being of normal size and functionality. In this case, the anomaly can only be detected with the help of special studies. Determination of the cause of agenesis should be carried out as accurately as possible and at an early stage to ensure the health and well-being of the child.

Severe cases of development of an embryonic defect associated with the congenital absence of any internal organ are diagnosed in children of the first year of life, less often in older children. Agenesis of the major gonads is more likely to be diagnosed in a newborn than Cassirer-Jabert syndrome. In terms of the frequency of occurrence of various types of disorders, this fetal defect is the leader in newborn women (65%), and among girls with gonadal agenesis it is 74%.

Congenital agenesis is often diagnosed as adrenal hypoplasia or virilism when diagnosing an orphan boy and girl from an orphanage. In this case, parental abuse of steroids and hormonal therapy for a boy or the establishment of corticosteroid deficiency, accompanied by virilism in a girl, is possible. If the absence of large gonads is detected in the postoperative period, it is advisable to conduct their genetic study.