Aleukia Alimentary-Toxic

Aleukia Alimentary-Toxic: symptoms, causes and treatment

Alimentary-toxic aleukia (AAT) is a rare disease that manifests itself as acute damage to the hematopoietic organs and hemorrhagic diathesis. The disease usually develops after eating food contaminated with toxins produced by molds of the genus Fusarium. In this article we will look at the symptoms, causes and treatment of AAT.

Causes of AAT

AAT is caused by toxins that are released by Fusarium under unfavorable conditions of grain storage and transportation. These toxins, known as trichothecenes, can lead to disruption of hematopoiesis and damage to blood vessels, leading to bleeding diathesis.

Symptoms of AAT

Symptoms of AAT may include fever, vomiting, diarrhea, and symptoms associated with blood disorders such as bleeding, bruising, and hemorrhages in the skin and mucous membranes. Patients may experience pallor, weakness and fatigue. In some cases, the development of acute liver failure may occur.

Diagnosis of AAT

Diagnosis of AAT is based on the clinical manifestations of the disease, as well as on laboratory blood tests. Patients with AAT usually experience a decrease in the number of white blood cells and platelets in the blood, as well as an increase in the level of liver enzymes.

Treatment of AAT

Treatment for AAT includes stopping the consumption of contaminated foods and prescribing anti-infective and anti-inflammatory drugs. In some cases, blood transfusions and the use of hormonal drugs may be required.

Prevention of AAT

Prevention of AAT includes proper storage and transportation of grain, as well as expert control of food quality. It is also recommended to wash fruits and vegetables thoroughly before eating and avoid eating food that may be contaminated with toxins.

In conclusion, AAT is a rare but serious disease that can lead to acute liver failure and other dangerous complications. Prevention and timely treatment can help prevent the development of this disease and ensure the patient's full recovery.

Aleukia is a severe form of anemia or leukopenia that occurs as a result of eating foods high in mycotoxins, such as mushrooms. This disease is often found in African and Asian countries, where there are certain types of fungi that can cause organ problems in humans and animals. The most common form of aleukia is allergic-toxic aleukia.

Aleukia is a group of diseases caused by toxins. The main pathogenic factor is the hemolytic poison of the plant fungus Fusarium celluloliticum. These fungi develop as red, white and black spots on bread, onions, garlic and other plant foods.

Most often, the hemotoxic (hemolytic) poison or fusarium hemotoxin is contained in the pulp of the bitter mass of garlic bulbs, since this part of the plant is the largest. Eating garlic in fresh, powdered and especially fried form (when cooking “garlic pans”, “garlic pastes”, etc.) in the presence of aleukia is highly undesirable, which is understandable: large liver fat reserves prevent the better secretion of gastric juice and enzymatic substances . The body cannot cope with the abundant excretion of toxic products, which can cause serious complications.

In aleika with fusarium etiology of toxicochemical origin, dicarbonylnitro derivatives of amino acids, lipid amino acids, funarylpyrones, furans, furanolidones, and furans are formed as metabolites. Dicarbonyl compounds disrupt the balance of SH groups in hemoglobin, activating enzymes that break down hemoglobin, and thereby activate hemolysis. Nitro derivatives block the coenzyme, causing cellular respiration along the anaerobic pathway, due to which hemolysis becomes possible in an environment of increased oxygen. Subsequently, these metabolites become the cause of the development of acute hemolysis, complicated by hypochloremic, metabolic or true convulsive crisis. Some metabolites exhibit a laxative effect. Furans take part in stimulating intestinal motor function and exhibit hepatotoxic and neurotoxic effects; have a mutagenic effect, inhibit both the immunological and phospholipase systems. Furanolides stimulate oxidative processes, cause depolarization of cell membranes, suppress the immune system and cells of the neurovascular system, activate alcohol dehydrogenase and glutamate decarboxylase, and reduce the glutamate content in muscles.