Erythrokeratoderma Variable

Erythrokeratoderma Variable Definition of the disease Erythrokeratosis (erythrokeratoderma) is a benign chronic disease of the skin, accompanied by the formation of lesions in the form of rough red spots. Refers to external pathologies of the skin associated with disturbances in its thickness and structure. The disease is chronic in nature, and in the human body the duration ranges from several weeks to a month and even several years. Manifestations include increased skin pigmentation (erythema), accompanied by peeling, thickening, roughness and cracking, as well as thickening of the stratum corneum. In this case, the formation of superficial or multiple small ulcerations or erosions on the skin of the feet and legs is possible. Spots on exposed areas, skin folds, or folds of the oral mucosa may become areas of hyperkeratosis, which can lead to suprabasal nail lesions. The disease occurs due to a disorder of the compensatory mechanisms of keratinization. The name erythrodysemia comes from the Greek word "erythes" - "pink" due to the fact that the disease first affects the toes. A phenomenon called erythrotanias - sudden redness of the fingers at the site of burst capillaries, is also considered one of the classic manifestations. At the initial stage of erythrokeratodema, there are few spots and slight pigmentation. In most cases, spontaneous self-healing occurs, but a protracted form can lead to disability and significant limitation of a person’s social activity. There are several options for the name of this type of disease, including: congenital hematopoietic rash, hereditary erythroderma, leg hirsutism, hemoglobinic eczema, Landerer-Lechenblast syndrome, sclerodermatous erythropathy, pigmented basal cell proliferation, digital pseudomelanoma.

General information This is a rare, rather severe skin disease, which is most often associated with inherited

Erythrokeratosis is a multisystem skin lesion characterized by a complex of symptoms involving certain areas of the epidermis, dermis and adjacent tissues, often in combination with widespread peripheral erythroderma. It is a rare disease that affects approximately one in three million people. The exact cause of the disease is unknown, but histological studies show the presence of pathological changes in the vascular endothelium and keratinocytes. However, the most common theory relates these symptoms to the tissue's immune response to various irritants, such as chemicals or viruses. Erythropathy is characterized by a variety of manifestations and includes many different forms, each of which is characterized by its own specific clinical course and set of symptoms. The most famous is the so-called “erythrokeratoma” - a limited area of ​​a spotty-brown, red, pinkish color with smoothed outlines and a densely expressed horny layer. Increased sensitivity develops after damage to the skin: acute injuries, minor overheating or hypothermia, contact with tearing (or crushing) clothing, tight shoes. The subacute form of the disease is characterized by a milder course with a protracted relapsing nature and often manifests itself in the form of a subsiding and newly growing, hyperpigmented lesion. A brief review of the world literature indicates a significant divergence of views on the pathogenesis of this dermatological condition, including diagnostic and treatment approaches, based on the details of the history of the description of the manifestation of erythropathy in a particular patient. Based on an extensive and critical review of articles by domestic and foreign authors concerning the etiopathogenesis, clinical picture, diagnosis and treatment of erythropathy, the most important details of the history of the disease and its main manifestations were noted, and a discussion among specialists regarding the etiological series of “erythropathy” was identified. The article proposes methods for resolving controversial issues that unite the efforts of specialists from different fields of knowledge.