Pemphigus vera (Pmphigus Acan-Tolytica)

Pemphigus vera (Pmphigus Acan-Tolytic): symptoms, treatment and prognosis

Pemphigus vera, also known as Pemphigus Acan-Tolytic, is a disease of unknown etiology, which is characterized by the appearance of blisters and erosions on the mucous membranes and skin, prone to peripheral growth, and toxicosis. The disease belongs to a group of autoimmune diseases that cause akaitolysis and the formation of intra-epidermal blisters.

Symptoms and course of the disease

The main form of Pemphigus True is pemphigus vulgaris, which usually begins on the mucous membrane of the mouth, sometimes the larynx, where thin-walled blisters form that quickly burst. Erosions are located on the unchanged mucous membrane.

Blisters with transparent contents appear on the skin, after opening which bright red erosions are formed that are prone to growth. Crusts may form on the surface of erosions. The surrounding skin is unchanged. In patients with Pemphigus vera, a positive Nikolsky sign is often observed.

Without treatment, the disease process progresses, the rashes merge, cover large areas of the skin, toxicosis develops, and fever is possible. Variants of Pemphigus vera include sebo-rheic, leaf-shaped and vegetative forms.

To diagnose Pemphigus Vera, fingerprint smears are used, in which acantholytic cells are detected on the surface of erosions.

Treatment of Pemphigus Vera

Corticosteroid drugs are initially prescribed in a loading dose (60-100 mg of prednisolone per day). After the onset of remission, the dose is gradually reduced to a maintenance dose (10-15 mg per day), which is administered continuously. Corticosteroids can be combined with cytostatics (methotrexate), gamma globulin, antibiotics, hyperbaric oxygenation. Withdrawal of corticosteroids or rapid reduction of their daily dose causes an exacerbation of the disease.

Prognosis of Pemphigus vera

Without treatment, the prognosis for Pemphigus Vera is poor. However, corticosteroids cause remission, sometimes persistent, allowing gradual cessation of treatment. The ability to work is limited in patients with Pemphigus Vera, especially in the presence of rashes on large surfaces of the body.

In conclusion, Pemphigus vera is a serious disease that can cause significant limitations in the patient's life. For successful treatment, it is necessary to consult a doctor in a timely manner and begin corticosteroid therapy, followed by a gradual reduction in dose. With proper treatment and regular follow-up with a doctor, the prognosis of Pemphigus vera can be improved.