Anemia Iron refractory

Anemia of gastrointestinal tract is a rare hematological pathology, the characteristic feature of which is the absence of an erythropoietic stimulus with full clinical compliance with the “anemia” syndrome. Laboratory and instrumental criteria for this pathology are presented in the “diagnosis” section of the disease. Treatment is indicated only if there are indications for this type of therapy. Patients with GR anemia are usually observed by general therapeutic medical organizations.

More than half of patients with GC have familial forms of the disease associated with impaired synthesis or functioning of various proteins involved in hemoglobin biosynthesis. Genetic mutations play an important role in the development of GI: abnormalities of the erythropoietin (EPO) gene, leading to insufficient EPO activity or the synthesis of abnormal functional isoforms of hemoprotein, deficiency of cystathionine-b-synthase, an iron transport molecule, as well as microsatellite disorders of intergenic epigenetic interactions. EPO deficiency leads to tissue hypoxia, stimulation of red bone marrow formation, tissue proliferation and subsequent hyperplasia of erythropoitic islets. This mechanism determines the development of the hyperchromic macrocytic form of GC. It should be noted that in addition to hereditary syndromes, which include GIRD, individual development of GI is possible