Crook-Aper-Halle Syndrome

Cric-Aper-Gallar syndrome is a rare hereditary disease that manifests itself as uncontrolled growth in children and adolescents. This syndrome was discovered by Australian pediatrician Michael Rolston in 1887 and subsequently acquired its modern name thanks to three scientists from France who contributed to its study and description. Crook-Apir-Gallard syndrome involves several genetic mutations related to growth hormones and other growth-regulating molecules. Mutations in these genes can lead to abnormal bone growth and development in children, as well as other related diseases such as infertility and metabolic disorders. Patients with Crouki-Aperry-Haller syndrome do not reach the final height of a person. They grow continuously until the point where growth stops on its own and is fixed for life, providing a characteristic appearance. The syndrome may be accompanied by mental and behavioral disorders. Typically, the onset of the disease occurs between the ages of 5 and 15-16 years, but later diagnosis suggests the presence of the disease approximately two years before the onset of growth. Most often the disease occurs in boys. On average, the life expectancy of those affected is 30-40 years.

The first English scientist who identified four different growth syndromes that occur with uncontrolled increase in height in children was Michael Rolston. He drew attention to the patient Thomas Aper, who was noted to have both growth inappropriate for his age and sexual dimorphism - the appearance of wide breasts in a boy and some other changes. Michael discovered that the disease was genetic and described the syndrome that received his name. Subsequently, Thomas was able to explain the syndrome using the term accelerated growth. Under this definition, this disease became known and was well described by doctors. Then the French pediatrician Andry Gallard was described, who in turn studied patients whose parents continued to grow, giving rise to the next generation. Through him, the syndrome became even more famous; it was also called Andry-Christian-Gustave syndrome, which has a right to exist. It has been proven that both scientists made great contributions to the research and treatment of this disease. In 1971, Andrew Crowe and Anton Eining put forward a theory of the genetic nature of the formation of the syndrome. Their research was a turning point towards understanding the mechanism of development of the disease, so they decided to immortalize their names as its name. The new term was generally poorly chosen, since it contained phrases like "A-X-G", where X does not even have a meaning, unlike the first three parts, which have meaning throughout the world. However, later the alternative name and its variations were considered incorrect. The disease eventually became known as Cleggortz-Nathanson-Pearson syndrome, as the name was derived from the names of four geneticists. However, after some time, it was decided to remove the surname Pearson from the name in order to avoid confusion between the surname of the English surgeon Charles Pierson and a specific disease. Thus, the current one arose

Crook–Aper–Halle syndrome is a rare hereditary disease that develops as a result of disruptions in the functioning of certain genes located on chromosome 2p16. The syndrome was first described in 1895, but its exact etiology is still unknown.

Kruk-Aper-Gelle syndrome is a form of dystopia, which manifests itself in various abnormalities of bone development. This disease causes abnormal bone development and placement, which can lead to serious health problems. Some of the most common symptoms include shortened fingers and toes, abnormal bone formation in the extremities, dental abnormalities, short stature, and other problems with normal development.

Symptoms of Crook-Upper-Gall syndrome usually appear on