Dysgenesis Gonads Asymmetric

Gonadal dysgenesis or dualizing dysplasia is a discrepancy in the development of the gonads in boys and girls. In this case, there is an increased development of the more developed side of the gonad and, accordingly, a lack of development of the opposite side. The significance of the problems in this area for healthcare is determined by the fact that 60-75% of newborns who have this pathology die. In addition, such rare diseases as ovarian tumor in men, Klinefelter syndrome, etc. are associated with severe congenital disorders of the process of sexual differentiation. The atypical location of the seminiferous tubules and their abnormal connection form the basis of the pathogenesis of gonadal dysgenesis. In a number of cases, the process of laying down primary germ cells starts, but in the second ontogenesis a transverse fold from the mesonephros is transformed into them. A stump is formed - a large terminal derivative of the outer layer of fused tubules that form the primary section of the reproductive system. At the level of the bend of the crest, the folds of the gland remain underdeveloped, and an unfolded ridge appears. It wraps several times around the Müllerian duct and this rounded sac, all elements of which in its structure are products of tubule cell division, can be located at the site adjacent to the mesonephric fusion at any angle. It takes approximately 30 to 55 days after birth for the ligamentous ridge to bifurcate. At this stage, division and inversion of germ cells occurs. From them, germ cells are produced and formed. The original arches move away from each other and parts of the common tissue are preserved to form normal gonads. Subsequently, they are gradually replaced by connective tissue consisting of organ cells, sometimes with the formation of cystic formations - cysts of the vaginal vault. Later veins are located in it. The transverse fold undergoes destructuring with the retraction of its retroperitoneal end. Initially, in the embryo, the structure of the embryological maternal genitalia depends on the location of the urethra (antimesenteric type, in which the canal goes around the ovary). Blue mutations, leading to disembryogenesis due to the action of embryonic factors, are also a key factor leading to the development of gonadal dysgenesis. Preimplantation testosterone is not able to take part in the process of formation of the gonads at different stages of embryogenesis. The consequences of insufficiency of embryo- and organogenesis depend on the affected area and the degree of its influence on the normal process of sex formation. The development of dysgenesis leads to a decrease in the production of sex hormones. In boys, there is an increase in a certain horn of the pituitary gland due to hCG production and delayed psychophysiological development. A disproportionately large left testicle leads to disruption of the menstrual cycle in girls. However, it is impossible to talk about the significant role of ectopia of virilizing gonads in females in dysfunction of the reproductive organs. Their involvement in the pathological disposition of the gonads is possible in connection with adrenoblasts with a transition through the retro- and paramesonephric system into the

Gonadal dysgenesis is a genetic disease that can lead to various abnormalities in the development of the genital organs in children and adolescents. One type of gonadal dysgenesis is asymmetric dysgenesis, which is characterized by uneven development of the gonads on one or both sides of the body. Some people with this condition may experience health problems such as difficulty developing secondary sexual characteristics, hormonal imbalances, infertility and other problems.

Gonadal dysgenesis can result from various genetic abnormalities. The cause of the pathology may be associated with a violation of the development of the gonads during embryonic development, when the formation of the gonads occurs. In some cases, dysgenesis may be caused by exposure of the fetus to certain factors, such as exposure to radiation during pregnancy or certain medications. Regardless of the cause, dysgenesis is usually inherited in an autosomal recessive manner, meaning that the disease is caused by a combination of two genes that are not normally expressed, and only in combination do they cause dysgenesis.