Nullisomia [At. Nullus Nothing, Zero + (Chromo) Som]

Nullisomy is a type of aneuploidy (abnormality in the number of chromosomes), in which one or more homologous pairs of chromosomes are missing from the genome. It can be caused by various factors such as mutation, disruption of meiosis, or random loss of chromosomes during gametogenesis.

Nullisomy can have various effects on the body. For example, people with trisomy 13 (three pairs of chromosome 13 instead of two) may have developmental delays, mental retardation, and other health problems. Women with monosomy X (missing one pair of X chromosomes) may experience Turner syndrome, which is characterized by delayed puberty, decreased uterine size, and infertility.

However, not all nullisomies are negative. Some may be beneficial, for example, men with monosomy Y (missing one pair of Y chromosomes) may develop unique traits such as a deep voice and increased muscle strength. In addition, some nullisomies can result in new genes and phenotypes, which can lead to the creation of new species of organisms.

Overall, nullisomy is an interesting genetic phenomenon and can have both positive and negative consequences for the health and evolution of living organisms.

Nullisomy is a type of aneuplinoid structural changes in the genome, in which one or more pairs of homologous chromosomal segments disappear from the set of chromosomes. This occurs due to chromosomal exchange, chromatids can also be called single chromosomes, they are called “dihomics”.

The deficiency of one pair of homologous somatic chromosomes is called monosomy, and if the deficiency is digomic (disomy), then both chromotides belong to the same chromosome set.

The most common variants of the nullisomal situation are among human genes on chromosomes 30–40, which account for more than 90% of the variability in the human genome, and can lead to various metabolic disorders and physical defects.

**Nullisomy** (translated from Latin as “lack of chromosomes”) is a type of karyotype abnormality in which one or more entire chromosome sets are lost. The literal translation is “Nothing + chromosome.”

Depending on the nature of the change in the set of chromosomes according to the haploid set, this anomaly is subsection