Scleroderma Limited

Limited scleroderma, or rounded scleroderma, is a rare skin disease in the form of a sharp induration of the subcutaneous tissue around the mouth, nose, eyes and face, along the nerve trunks and muscles, mainly with syringomyelia, occasionally localized elsewhere. May be accompanied by perineural compaction. External manifestations of sclerosing ligamentitis are represented by atrophy of the skin, pain, impaired sensitivity and trophism of the striated muscles. The main cause of the pathological process is unknown.

The first limited research in the field of scleroodymia was carried out by American scientists John Darwin and Stephen Goldblatt in the middle of the last century. At the same time, this disease began to be actively studied in Europe, and soon the idea arose to introduce a new concept and make a separate nosological form out of it.

In Russia, the discoverer of this problem was D.O. Akhtyamov. He found that sclerotic lesions of the nerve trunk are not always accompanied by the formation of stones, and when scraping the changed skin, cobblestones do not fall out. There are several clinical types of limited sclerodutia. Thus, there are three main forms of the disease:

microscle

It is an acquired or congenital skin disease with no definite onset, which does not imply predisposing factors. It is characterized by diffuse infiltration of all layers of the dermis and atrophy of the subcutaneous tissue in the area of ​​the cervical lymph nodes. In subacute cases, diagnosis may be difficult or absent; a diagnosis cannot be made based on diagnostic data. Transient Raynaud's syndrome may be present.

Features of limited scleroderma: * the lesions are asymmetrical, merging, most often on the lateral surfaces of the toes, in the area of ​​the hand on the palmar side,

Scleroderma limited (SCL), or scleredoderma limited (scleroedomas), is a rare skin disease that can occur in anyone, regardless of age and gender. It is characterized by flat-type spots that can develop in any part of the body. The most common sites include the face, neck, fingers and toes, and less commonly the torso, buttocks, elbows, knees and genitals. This is an autoimmune disease, that is, its occurrence is associated with the production of excess antibodies in the body, which can lead to a violation of the integrity of the skin and other related problems. The prevalence of scleroderma is limited to a few countries in Europe and North America. More than 20 cases per year are reported, but this number cannot be considered reliable due to the difficulty in making a diagnosis without microscopic examination or skin biopsy.

Symptoms and Diagnosis of Scleroderma limited Symptoms of scleroderma limited include erythematous skin lesions (erythemas) that appear on the face,

Scleroderma is limited - rare and in most cases chronic, with the development of lymphoid hyperemia, lichenification, telangiectasia and fibrotic changes in the dermis - the so-called. sclerodactyly. As a rule, they are localized in the proximal limbs. They are often evolutionary in nature and usually progress after psoriasis has been cured, accompanied by immunological changes. The histological picture is characterized by capillary dilatation, edema, acanthosis and the formation of perivascular lymphoid infiltrates and telangiepithal nevi. The results of the reaction to antinuclear factor and increased complement fixation are considered positive. When treated with nitrogenous compounds, keratohyaline balls are replaced by granular basophilia; The edges of the papules smooth out as the process improves.