Wegener's Granulematosis

Wegener's granulomatosis is a rare systemic disease manifested in a combination of stromal and vascular inflammatory changes in the lungs and other organs and is an autoimmune disease. It usually appears after pulmonary tuberculosis or connective tissue infection. The disease is severe, often leading to complications and multiple systemic destruction. Early detection of the disease is important to improve prognosis. Treatment is with immunosuppressants, cyclophosphamide, corticosteroids, rituximab, plasmapheresis, or bone marrow transplantation. The prognosis for severe infection depends on treatment tactics and underlying diseases.

(Wegener's granulomas - granulomatous vasculitis, idiopathic atypical granulomatous angiitis)

Wegener's granulomatosis is often referred to as vascular and interstitial involvement by noncutaneous and nonrheumatic granulomas accompanied by fibrosis of the renal arterioles and tubules. Granulomas are tissue inclusions consisting of cells lining small and large blood vessels. The most striking morphological sign of granulitis-active vasculitis is their presence in the lymphatic vessels and vessels feeding various organs.